2+ min ago   (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...

42+ min ago   (101+ words) Higher income has long been treated as a reliable shield against chronic disease, but a sweeping new analysis of female breast cancer survivors in the United States suggests that this protection is anything but uniform. Drawing on four years of…...

1+ hour ago   (55+ words) Immunotherapy has transformed the outlook for people with advanced bladder and kidney cancer. Drugs known as immune checkpoint inhibitors, which block molecular brakes such as CTLA-4, PD-1 and PD-L1 to unleash the immune system against tumours, have dramatically improved long-term…...

1+ hour, 22+ min ago   (53+ words) Triple-negative breast cancer is the form of the disease that clinicians fear most. Lacking the three molecular targets — the estrogen receptor, the progesterone receptor and the HER2 protein — that anchor modern targeted therapies, it leaves patients with fewer options and a…...

1+ hour, 38+ min ago   (55+ words) Immune checkpoint inhibitors have rewritten the outlook for some patients with gastrointestinal cancers, turning once uniformly fatal diagnoses into manageable chronic conditions for a fortunate minority. Yet for every dramatic response there are many more patients whose tumours barely flinch,…...

1+ hour, 47+ min ago   (75+ words) Gastric cancer continues to rank among the most lethal malignancies worldwide, and a new study published in Medical Oncology has identified a molecular culprit that may explain how tumors in the stomach not only grow aggressively but also dismantle the…...

1+ hour, 47+ min ago   (651+ words) Patients with extensive-stage small cell lung cancer, one of the most difficult malignancies to treat once first-line therapy fails, may soon have a more convenient way to receive an immunotherapy that has already changed the treatment landscape....

1+ hour, 47+ min ago   (539+ words) A mitochondrial enzyme long known simply as a workhorse of cellular energy production has been revealed as a powerful suppressor of colorectal cancer, one of the most common and deadly malignancies worldwide....

1+ hour, 47+ min ago   (721+ words) A new qualitative study from China offers one of the most detailed maps to date of what patients with cardiovascular-kidney-metabolic syndrome actually value about their health, and the picture that emerges is strikingly broader than the clinical targets that dominate…...

3+ hour ago   (746+ words) A new commentary published in the Journal of Cancer Research and Clinical Oncology is challenging how exceptional individual responses to an experimental multiple myeloma drug should be interpreted, warning that remarkable case reports can inadvertently obscure evidence that a treatment…...